Transforming growth factor-β1 gene polymorphism in psoriasis vulgaris
نویسندگان
چکیده
منابع مشابه
Transforming growth factor beta1 gene polymorphism in rheumatoid arthritis.
OBJECTIVE Rheumatoid arthritis (RA) is a chronic inflammatory disease and synovial cells, antigen presenting cells, lymphocytes, and their cytokines might be associated with the disease. Transforming growth factor beta1 (TGFbeta1) has been reported to have important roles in unresolved inflammation, immune suppression, fibrosing processes, and angiogenesis. TGFbeta1 is highly expressed in joint...
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Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine involved in many physiological and pathological processes. Its actions are complex and in vitro experiments and clinical findings suggest that under different circumstances it may have opposing biological effects [1]. There are in vitro experimental data indicating that it may be both anti-atherogenic [2] and proatherogenic [3...
متن کاملAssociation of a polymorphism of the transforming growth factor-beta1 gene with cerebral amyloid angiopathy.
BACKGROUND A recent study showed that transforming growth factor-beta1 (TGF-beta1) induces amyloid-beta deposition in cerebral blood vessels and meninges of a transgenic mouse model of Alzheimer's disease (AD), and that TGF-beta1 mRNA levels are correlated with cerebral amyloid angiopathy (CAA) in human AD brains. A T/C polymorphism at codon 10 in exon 1 of the TGF-beta1 gene has been reported ...
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All three isoforms of transforming growth factors beta (TGF-betal, TGF-beta2, and TGF-beta3) are secreted as latent complexes and activated extracellularly, leading to the release of the mature cytokines from their noncovalently associated proregions, also known as latency-associated peptides (LAPs). The LAP region of TGF-beta1 was expressed in a baculovirus expression system and purified to ho...
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Psoriasis is a lifelong disorder characterized by approximately 8-fold reduction of the duration of normal skin keratinocyte cell cycle and 2-fold increase of the number of dividing cells. Multiple genes, several environmental factors, and immune system alterations are involved in the pathogenesis of psoriasis. Hyperleptinemia is associated with psoriasis and leptin acts as an angiogenic factor...
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ژورنال
عنوان ژورنال: Clinical, Cosmetic and Investigational Dermatology
سال: 2018
ISSN: 1178-7015
DOI: 10.2147/ccid.s171403